A new approach to wound healing and infection neutralization

Published August 18, 2022
Categories: Health Science
approach to wound healing

Scientists at the University of Calgary have been able to develop a new approach to neutralize healing skin infections rooted in harmful bacteria in the body. The results of the research were published in the journal Nature by Dr. R. Kratofil and several co-authors, in particular, D. Deniset, head of the research group that worked to identify and form a new method of treating wounds and bacterial infections.

Dr. Kratophil said that, of course, this approach is not final, and many more experiments are needed to help develop the final model. In any case, this is a fundamental discovery that has become the key to the ability of doctors not only to eliminate the infection in the body, but to restore tissues destroyed by harmful effects.

Previously, scientists believed monocytes and neutrophils are involved in cleaning those skin areas being infected with bacteria, that is, where the inflammatory infectious process is actively developing. The combined cells action is a first-line defense our immune system has built to prevent contagion throughout the body.

However, the results of new studies have shown that the natural code of monocytes has such a function as a contributing effect in wound healing. Monocytes regulate leptin levels and force vessels’s work, which helps damaged structures to regenerate faster and produce new celulas. In addition, monocytes generate ghrelin, a hormone also promoting the speedy healing of wounds.

Relationship between regenerative processes in tissues and the action of metabolic hormones

When a person is in a state of hunger, ghrelin is produced in the stomach. After the body receives food, fat cells produce leptin, which gives satiety. The balance between these two hormones has long been considered necessary only to regulate and maintain proper metabolism. However, scientists have found that it is closely related to tissue regeneration and immune mechanisms.

Implementing techniques such as in vivo microscopy, scientists were able to observe living organisms and visualize immune reaction to exposure to Staphylococcus aureus bacteria in animals.

Staphylococcus aureus is a harmful microorganism that “settles” on the skin or in the nasal cavity. This microbe is a catalyst for the development of many infectious ailments, in particular, the appearance of boils and abscesses. In addition, through the background of the action of Staphylococcus aureus, endocarditis and pneumonia develop.

After S. aureus enters the body, immune parts are stirred up, using all possible resources. Neutrophils actions are aimed at destroying bacteria, and monocytes – at tissue regeneration for after skin infection elimination. If there is an insufficient amount of monocytes in the body, leptin is produced in increased volumes – this contributes to delayed wound healing and the formation of rough scars.

What do the research results say?

As Dr. Kratophil said, the importance of the experiments and studies carried out lies in the fact that scientists were able to shift the paradigm that says only the participation of monocytes and neutrophils in cleansing the body of bacteria. Researchers can now confidently state monocytes have a significant role in healing skin infection.

The research team led by Dr. Kubes stated the research carried out is the key to the introduction of metabolic hormones in microbiology and immunology. It’s assumed further experiments will be able to show ghrelin and leptin reaction to other diseases, in particular, to cancer cells.

Following actions

The following studies are aimed at better comprehending immune structures’ functions, how they behave when infections enter organisms. Among other things, scientists want to find out how neutrophils themselves are cleared of bacteria. It’s planned to find out other neutrophil functions, besides neutralizing bacteria.

Related insights

December 8, 2022
Categories: Health

Nanoparticles Upgraded to Deliver Killer Sting on Recalcitrant Tumors

Adaptor proteins called STING (stimulator of interferon genes) aid the immune system in identifying pathogens and cancerous cells. Drugs that...
December 8, 2022
Categories: Health

How to Prevent Hearing Loss Caused by Antibiotics

Hearing loss caused by antibiotics can be prevented by biological pathways as suggested by scientists at IU School of Medicine....
December 8, 2022
Categories: Health

One drug to fight both muscle and bone deterioration

In a recent research made public in an open-access, peer-reviewed journal Bone Research, scientists from Japan set up a new drug test system...
December 8, 2022
Categories: Health

New liquid biopsy detects signs of breast cancer in early-stage patients

The scientists from USC Michelson Center CSI-Cancer have determined that a laboratory analysis of blood under the name of a liquid...
December 1, 2022
Categories: Science

Researchers created a new surgical training model for cancer surgery

Konnyaku, a prepared jelly formed from the konjac plant’s bulb, has been efficiently used by scientists from Nagοya University to...

Have any questions?

Send us a request and we will contact you as soon as possible.


We are in social networks

  • The goal that we have set for ourselves is the acquisition by the human body of the ability to remain young and healthy as long as possible – practically, the acquisition of immortality by a person.

    A young man at 100 years of age? Why not? And this is just the tip of the iceberg of our plans.

  • The main and most global goal of the project is to gain immortality. However, to achieve this goal, there is a lot of work to be done: from introducing the latest developments in medical practice, which already now can significantly improve health and prolong life, to conducting scientific research that will help achieve our global goal.

  • A fund or a company interested in investing in our project can contact us via the contact form to clarify all the details. The main condition is the sharing of project values ​​and the desire to change the world for the better together with us.

    In addition, we plan to issue our own NFT collection, by purchasing which you will also be able to invest in the project.

  • Since we create the ELC project from scratch and fully cover all our activities in social networks, you can learn about all promotions and developments from our official pages and website. One of the first public results will be the presentation of the project at the Eternity Life Forum, where we will present our project, with its ideas and developments.