grain-elipse1
grain-elipse

A specific enzyme has been discovered to play a crucial and dual role in cell health

Published November 14, 2022
Categories: Science
Eternity Life Clinics - A specific enzyme has been discovered to play a crucial and dual role in cell health

In UMass Amherst, researchers claim to have made a significant advancement in our understanding of how cells respond to a stressful environment. The scientists found out that a damage-fixing enzyme named ClpX may adapt to fluctuating degrees of cellular unit energy to maintain cell health as well as mutate to remedy a variety of cellular units applying bacteria. The study was released in Cell Reports.

How do cells react to stressful conditions?

Two distinct proteases—Lon and ClpX—each of which is programmed to detect a different damaging protein—were the focus of the research. Long believed to act as locks, these proteases could only unlock one type of lock at a time, and if either were missing from a cell, negative side effects would appear.

AAA+ proteases in bacteria, such Lοn and ClpΧP, break down substrates with great selectivity. These devices use the ATP hydrolysis energy to drive the unfolding and destruction of their target substrates. Here, we demonstrate that a mutation in the ATP binding site of ClpΧ changes protease specificity to facilitate decline of substrates that are typically Lon-restricted.

However, this ClpX mutant performs poorer at destroying ClpXP targets, indicating a simple way to change a protease’s preferred substrate balance. In vitro, wild-type ClpΧP similarly to the shifting selectivity of mutant ClpΧP, which has changed ATP hydrolysis kinetics, degrades Lon-restricted substrates more quickly when ATP levels are decreased. These findings lead us to hypothesize that ATP hydrolysis rates adjust protease selectivity in addition to driving substrate unfolding and decline.

The team of scientists conducted a series of studies in which they deleted Lon from a group of bacteria derived from the same mother cell, and as a result, some of them appeared to survive. They observed that ClpX can change to carry out a Lon functions, although it loses some of its ClpX characteristics.

The team’s another finding was that, under the correct circumstances, wild ClpX can also carry out some of Lon’s responsibilities. This was discovered while determining precisely how the ClpΧ modification permitted the protease to broaden its functions.

As found out, ClpΧ is sensitized to ATP, the chemical substance that provides all cells with their energy. ClpΧ concentrates on its responsibilities when ATP levels are good, but if insufficient, it abruptly cleans up after Lοn. This is a significant advance in our fundamental knowledge of how cells function.

Related insights

December 1, 2022
Categories: Science

Researchers created a new surgical training model for cancer surgery

Konnyaku, a prepared jelly formed from the konjac plant’s bulb, has been efficiently used by scientists from Nagοya University to...
November 22, 2022
Categories: Science

Robotic drug capsule can carry medications to the gut

Someday, an MIT-created robotic capsule filled with medications might be able to take the place of medical injections. When this...
November 14, 2022
Categories: Science

Researchers develop a novel technique to monitor the effectiveness of treatment for cancer lesions more precisely

To better inform the development of new cancer treatments, researchers from the University of Colorado Cancer Center on the Anschutz...
November 14, 2022
Categories: Science

A specific enzyme has been discovered to play a crucial and dual role in cell health

In UMass Amherst, researchers claim to have made a significant advancement in our understanding of how cells respond to a...
November 10, 2022

Join our DAO and change the odds

ELC is an innovative cooperative tool for the decentralized development of life extension technologies. Our main mission is to accelerate...
Prev
Next

Have any questions?

Send us a request and we will contact you as soon as possible.

loader

We are in social networks

  • The goal that we have set for ourselves is the acquisition by the human body of the ability to remain young and healthy as long as possible – practically, the acquisition of immortality by a person.

    A young man at 100 years of age? Why not? And this is just the tip of the iceberg of our plans.

  • The main and most global goal of the project is to gain immortality. However, to achieve this goal, there is a lot of work to be done: from introducing the latest developments in medical practice, which already now can significantly improve health and prolong life, to conducting scientific research that will help achieve our global goal.

  • A fund or a company interested in investing in our project can contact us via the contact form to clarify all the details. The main condition is the sharing of project values ​​and the desire to change the world for the better together with us.

    In addition, we plan to issue our own token, by purchasing which you will also be able to invest in the project.

  • Since we create the ELC project from scratch and fully cover all our activities in social networks, you can learn about all promotions and developments from our official pages and website. One of the first public results will be the presentation of the project at the Eternity Life Forum, where we will present our project, with its ideas and developments.