Expanding bioprinting possibilities. New developments

Published September 7, 2022
Categories: Science

Data from USA Health and Community Services University say that annually 17 patients die due to excessively long waiting times for organs transplantation. One possible way to shorten the queue for transplantation is creation of bio-materials compatible with human nature: with them organs can be 3D printed and tissues can be formed. So far, nevertheless, scientists’ efforts have not been successful: modernized hydrogel bio-ink has not been able to take root in human organisms and adequately maintain the functioning of cellulars in compound tissues.

Pennsylvania researchers created nano-engineered bio-material granular inks composed of self-assembling microscopic particles whereby they have achieved preliminarily unattainable tissues fidelity, structure porousness and cells integration. Studies’ results and development description were released in Small edition.

Possibilities of new bio-inks. Their importance in creating three-dimensional models of organs

Amir Sheikhi, a scientist in the Department of Chemical Engineering at Pennsylvania University, said researchers break restrictions of implementing hydrogels to 3D-print organs. The nano-particles now making up the ink exhibit and retain micro porousness well, and improved printing characteristics improving form in terms of accuracy.

The basis for most of bio-inks existing today is a hydrogel, a polymeric substance that can hold water in large quantities whilst keeping its structure. It has nano-pores limiting the interaction between cellulars, and the circulation of oxygen. These organs need correction in order to permit cell migration, as well as proper inhibition of ink confluence with tissues.

Main restriction for 3D-bioprinting with hydrogel bio-materials is to find and establish a balance between cells’ vitality and form accuracy; it’s controlled by hydrogel porousness and its rigidity. According to Mr. Sheikh, raising the stiffness of the substance leads to an improvement in shape accuracy parameter of structures, nevertheless, it can reduce porosity; thus, it’s a threat to cells’ vitality.

To solve this problem, researchers began to use microgel to create a tissue scaffold. Its main difference from bulk gel is that scaffolds made of this substance can form porous three-dimensional structures without losing their accuracy.

But, as experts say, cells movement and preservation of their vitality still remain a certain problem. In order to get the necessary characteristics for 3D organs, hydrogel tissues must fit snugly together while limiting spaces between them. This can adversely affect the porosity of tissues, accordingly, cells’ mobility and vitality.

Pennsylvania specialists are working on exactly how to preserve characteristics of granular hydrogel, increasing its adhesiveness and adjusting its composition. Thus, hydrogel structures will “stick” to each other, preserving the integrity of small-scale pores.

According to scientists, possibilities of this mechanism may cover other granular developments, which consist of hybrid hydrogels. These structures could be made with similar nano-particles and implementation of mechanisms such as charge induction, reversible bonding, and more.

Scientists intend to investigate all the potentials of implementing nano-engineered bio-inks for their further use for three-dimensional tissue modeling. By focusing on solving problems such as the imperfection of bio-materials, researchers will be able to grow new possibilities for creation of functional organs and expand horizons of bio-engineering.

Related insights

September 29, 2022
Categories: Health Science

CRISPR-Based HIV Gene Therapy Administered To First Human Patient

Scientists at the Lewis Katz School of Medicine at Temple University and representatives of Excision BioTherapeutics together succeeded in applying...
September 28, 2022
Categories: Science

How long did our ancestors live?

Looking at the possibilities of modern medicine and the variety of healthy diets, it is easy to assume that our...
September 23, 2022
Categories: Science

Scientists are using AI to create new proteins

Tremendous developments in the field of computer science open up multiple possibilities and due to it biologists can dream up...
September 21, 2022
Categories: Health

Food safety tips for climate changing era

Climate changes, which have been taking place on our planet over the past decades at a rapid pace, is one...
September 21, 2022
Categories: Science

Universal Artificial Blood

Japanese researchers have managed to invent artificial blood, unique in its properties. The outcomes and description of study were demonstrated...

Have any questions?

Send us a request and we will contact you as soon as possible.


We are in social networks

  • The goal that we have set for ourselves is the acquisition by the human body of the ability to remain young and healthy as long as possible – practically, the acquisition of immortality by a person.

    A young man at 100 years of age? Why not? And this is just the tip of the iceberg of our plans.

  • The main and most global goal of the project is to gain immortality. However, to achieve this goal, there is a lot of work to be done: from introducing the latest developments in medical practice, which already now can significantly improve health and prolong life, to conducting scientific research that will help achieve our global goal.

  • A fund or a company interested in investing in our project can contact us via the contact form to clarify all the details. The main condition is the sharing of project values ​​and the desire to change the world for the better together with us.

    In addition, we plan to issue our own token, by purchasing which you will also be able to invest in the project.

  • Since we create the ELC project from scratch and fully cover all our activities in social networks, you can learn about all promotions and developments from our official pages and website. One of the first public results will be the presentation of the project at the Eternity Life Forum, where we will present our project, with its ideas and developments.