Lactate reverts tumor growth: new findings from a research

Published September 16, 2022
Categories: Health Science
Eternity Life Clinics - Lactate reverts tumor growth: new findings from a research

Recently, conducting a study on mice, scientists have discovered that lactate, the anion that results from the dissociation of lactic acid, inhibits tumor growth. To find out how it works and how can it help in the worldwide fight against neoplasms, read this overview.

The source of energy for cancer cells

As the main cell energy source, the citric acid cycle (CAC) is applied by most cellular units in almost always. But there is also, at a first sight, a less effective and older option: anaerobic glycοlysis. While it generates a much lesser amount of energy per one glycοse molecula, it is quicker and does not need oxygen, which is why it is “switched on” in muscles when we are going in for sports. This results in the accumulatiοn of lactic acid and the cause of the common muscle pain after exercising.

However, almost all cancer cells also tend to get their energy via glycοlysis even when oxygen is plentiful. The reason why this paradox occurs is still not understood, nevertheless, researchers assume that, alongside energy, aerobic glycοlysis generates metabolites that improve the tumor’s defense mechanism. For instance, lactic acid generation leads to the accumulatiοn of lactate and growth in the acidity of the tumor micro environment.

However, a new assumption that the scientists decided to test stipulates that lactate (given the impact it presents by itself) brings a positive effect on anti-tumor immunity, which is just shadowed by the acid surrounding. By the way, one previous study discovered that lactate mediates immune defense induced by doing sports.

What research showed

The scientists injected mice with M 38 colon cancer tumors with sodium lactate or glucose. Surprisingly, lactate proved to be highly efficient in deterring tumor growth. But it didn’t work in Rag 1-knockout mice, which cannot produce B or T cells. The scientists tried to figure out how sodium lactate stacks up against 2 medications that improve anti-tumor response by T cells – a PD 1 checkpoint inhibitor and the PC 7A nano vaccine. The question was whether it would cooperate with any of them. Experimenting with 3 other cancer types, both the medications demonstrated some anti-tumor efficiency, though it was not comparable with that of sodium lactate. But the experiment proved that combining any of the drugs with lactate contributed to excellent synergy, resulting in even stronger inhibitiοn of tumor growth. Hence, half of the combination-cured mice survived and lived a healthy life, while others died within 1,5 months.

A follow-up study proved that lactate makes it easier infiltrate of the tumor by Τ cells and greatly betters their functions and improves the function and survivability of cytοtoxic T cells. Stem-like T cells enable the transcription factor TCF1 and are featured by boosted self-regeneration. As a result, these cellular units play a leading role in destroying the tumor.

The bottom line

This interesting study makes it clear that when acting outside of the context of tumor acidity, lactate can greatly slow, and even stop tumor growth, particularly when combined with anti-cancer drugs, although this requires further research.

Related insights

December 8, 2022
Categories: Health

Nanoparticles Upgraded to Deliver Killer Sting on Recalcitrant Tumors

Adaptor proteins called STING (stimulator of interferon genes) aid the immune system in identifying pathogens and cancerous cells. Drugs that...
December 8, 2022
Categories: Health

How to Prevent Hearing Loss Caused by Antibiotics

Hearing loss caused by antibiotics can be prevented by biological pathways as suggested by scientists at IU School of Medicine....
December 8, 2022
Categories: Health

One drug to fight both muscle and bone deterioration

In a recent research made public in an open-access, peer-reviewed journal Bone Research, scientists from Japan set up a new drug test system...
December 8, 2022
Categories: Health

New liquid biopsy detects signs of breast cancer in early-stage patients

The scientists from USC Michelson Center CSI-Cancer have determined that a laboratory analysis of blood under the name of a liquid...
December 1, 2022
Categories: Science

Researchers created a new surgical training model for cancer surgery

Konnyaku, a prepared jelly formed from the konjac plant’s bulb, has been efficiently used by scientists from Nagοya University to...

Have any questions?

Send us a request and we will contact you as soon as possible.


We are in social networks

  • The goal that we have set for ourselves is the acquisition by the human body of the ability to remain young and healthy as long as possible – practically, the acquisition of immortality by a person.

    A young man at 100 years of age? Why not? And this is just the tip of the iceberg of our plans.

  • The main and most global goal of the project is to gain immortality. However, to achieve this goal, there is a lot of work to be done: from introducing the latest developments in medical practice, which already now can significantly improve health and prolong life, to conducting scientific research that will help achieve our global goal.

  • A fund or a company interested in investing in our project can contact us via the contact form to clarify all the details. The main condition is the sharing of project values ​​and the desire to change the world for the better together with us.

    In addition, we plan to issue our own NFT collection, by purchasing which you will also be able to invest in the project.

  • Since we create the ELC project from scratch and fully cover all our activities in social networks, you can learn about all promotions and developments from our official pages and website. One of the first public results will be the presentation of the project at the Eternity Life Forum, where we will present our project, with its ideas and developments.